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1

Palladium-Catalyzed Intermolecular Alkenylation of Indoles by Solvent-Controlled Regioselective CH Functionalization

Neil P. Grimster, Carolyn Gauntlett, Christopher R. A. Godfrey, Matthew J. Gaunt

Journal:

Angewandte Chemie International Edition

Year:

2005

Language:

english

File:

PDF, 350 KB

english, 2005

2

Human aspects of vibration and noise in helicopters

C.E.P. Jackson, W.F. Grimster

Journal:

Journal of Sound and Vibration

Year:

1972

Language:

english

File:

PDF, 1.72 MB

english, 1972

3

Inhibition of Mcl-1 through covalent modification of a noncatalytic lysine side chain

Akçay, Gizem, Belmonte, Matthew A, Aquila, Brian, Chuaqui, Claudio, Hird, Alexander W, Lamb, Michelle L, Rawlins, Philip B, Su, Nancy, Tentarelli, Sharon, Grimster, Neil P, Su, Qibin

Journal:

Nature Chemical Biology

Year:

2016

Language:

english

File:

PDF, 1.01 MB

english, 2016

4

Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, Part 2

Kettle, Jason G., Åstrand, Annika, Catley, Matthew, Grimster, Neil P., Nilsson, Magnus, Su, Qibin, Woessner, Richard

Journal:

Expert Opinion on Therapeutic Patents

Year:

2016

Language:

english

File:

PDF, 780 KB

english, 2016

5

Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, Part 1

Kettle, Jason G., Åstrand, Annika, Catley, Matthew, Grimster, Neil P., Nilsson, Magnus, Su, Qibin, Woessner, Richard

Journal:

Expert Opinion on Therapeutic Patents

Year:

2016

Language:

english

File:

PDF, 777 KB

english, 2016

6

Palladium-Catalyzed Intermolecular Alkenylation of Indoles by Solvent-Controlled Regioselective CH Functionalization

Neil P. Grimster, Carolyn Gauntlett, Christopher R. A. Godfrey, Matthew J. Gaunt

Journal:

Angewandte Chemie

Year:

2005

Language:

english

File:

PDF, 350 KB

english, 2005

7

Palladium-Catalyzed Intermolecular Alkenylation of Indoles by Solvent-Controlled Regioselective C-H Functionalization.

Neil P. Grimster, Carolyn Gauntlett, Christopher R. A. Godfrey, Matthew J. Gaunt

Journal:

Year:

2005

File:

PDF, 24 KB

2005

8

ChemInform Abstract: Synthesis and Reactivity of Rhodium(II) N-Triflyl Azavinyl Carbenes.

Neil Grimster, Li Zhang, Valery V. Fokin

Journal:

Year:

2010

Language:

english

File:

PDF, 72 KB

english, 2010

9

ChemInform Abstract: Alkynes to (E)-Enolates Using Tandem Catalysis: Stereoselective anti-Aldol and syn-[3,3]-Rearrangement Reactions.

Neil P. Grimster, Donna A. A. Wilton, Louis K. M. Chan, Christopher R. A. Godfrey, Clive Green, Dafydd R. Owen, Matthew J. Gaunt

Journal:

Year:

2010

Language:

english

File:

PDF, 49 KB

english, 2010

10

Preparation of kinase-biased compounds in the search for lead inhibitors of kinase targets

Justine Y.Q. Lai, Steven Langston, Ruth Adams, Rebekah E. Beevers, Richard Boyce, Svenja Burckhardt, James Cobb, Yvonne Ferguson, Eva Figueroa, Neil Grimster, Andrew H. Henry, Nawaz Khan, Kerry Jenkin

Journal:

Medicinal Research Reviews

Year:

2005

Language:

english

File:

PDF, 305 KB

english, 2005

11

Parallel synthesis of 1,2,4-trisubstituted imidazoles via N-alkyl-N-(β-keto)amides using a carbazate linker

James M. Cobb, Neil Grimster, Nawaz Khan, Justine Y.Q. Lai, Helen J. Payne (née Gold), Lloyd J. Payne, Tony Raynham, Jess Taylor

Journal:

Tetrahedron Letters

Year:

2002

Language:

english

File:

PDF, 154 KB

english, 2002

12

Alkynes to (E)-enolates using tandem catalysis: stereoselective anti-aldol and syn-[3,3]-rearrangement reactions

Neil P. Grimster, Donna A.A. Wilton, Louis K.M. Chan, Christopher R.A. Godfrey, Clive Green, Dafydd R. Owen, Matthew J. Gaunt

Journal:

Year:

2010

Language:

english

File:

PDF, 441 KB

english, 2010

13

Cu(II)-Catalyzed Direct and Site-Selective Arylation of Indoles Under Mild Conditions

Grimster, Neil P., Gaunt, Matthew J., Phipps, Robert J.

Journal:

Journal of the American Chemical Society

Year:

2008

Language:

english

File:

PDF, 857 KB

english, 2008

14

Binding of 3,4,5,6-Tetrahydroxyazepanes to the Acid-β-glucosidase Active Site: Implications for Pharmacological Chaperone Design for Gaucher Disease

Orwig, Susan D., Tan, Yun Lei, Grimster, Neil P., Yu, Zhanqian, Powers, Evan T., Kelly, Jeffery W., Lieberman, Raquel L.

Journal:

Year:

2011

Language:

english

File:

PDF, 2.03 MB

english, 2011

15

Synthesis of Selective Agonists for the 7 Nicotinic Acetylcholine Receptor with In Situ Click-Chemistry on Acetylcholine-Binding Protein Templates

Yamauchi, J. G., Gomez, K., Grimster, N., Dufouil, M., Nemecz, A., Fotsing, J. R., Ho, K.-Y., Talley, T. T., Sharpless, K. B., Fokin, V. V., Taylor, P.

Journal:

Molecular Pharmacology

Year:

2012

Language:

english

File:

PDF, 2.51 MB

english, 2012

16

Generation of Candidate Ligands for Nicotinic Acetylcholine Receptors via in situ Click Chemistry with a Soluble Acetylcholine Binding Protein Template

Grimster, Neil P., Stump, Bernhard, Fotsing, Joseph R., Weide, Timo, Talley, Todd T., Yamauchi, John G., Nemecz, Ákos, Kim, Choel, Ho, Kwok-Yiu, Sharpless, K. Barry

Journal:

Journal of the American Chemical Society

Year:

2012

Language:

english

File:

PDF, 2.02 MB

english, 2012

17

Expedient Synthesis of MLN1251, A CCR5 Antagonist for Treatment of HIV

Rönn, Magnus, McCubbin, Quentin, Winter, Steve, Veige, Melanie K., Grimster, Neil, Alorati, Tony, Plamondon, Louis

Journal:

Organic Process Research & Development

Year:

2007

Language:

english

File:

PDF, 117 KB

english, 2007

18

Aromatic Sulfonyl Fluorides Covalently Kinetically Stabilize Transthyretin to Prevent Amyloidogenesis while Affording a Fluorescent Conjugate

Grimster, Neil P., Connelly, Stephen, Baranczak, Aleksandra, Dong, Jiajia, Krasnova, Larissa B., Sharpless, K. Barry, Powers, Evan T., Wilson, Ian A., Kelly, Jeffery W.

Journal:

Journal of the American Chemical Society

Year:

2013

Language:

english

File:

PDF, 1.48 MB

english, 2013

19

Synthesis and Reactivity of Rhodium(II) N -Triflyl Azavinyl Carbenes

Grimster, Neil, Zhang, Li, Fokin, Valery V.

Journal:

Journal of the American Chemical Society

Year:

2010

Language:

english

File:

PDF, 277 KB

english, 2010

20

Toward the Molecular Mechanism(s) by Which EGCG Treatment Remodels Mature Amyloid Fibrils

Palhano, Fernando L., Lee, Jiyong, Grimster, Neil P., Kelly, Jeffery W.

Journal:

Journal of the American Chemical Society

Year:

2013

Language:

english

File:

PDF, 3.08 MB

english, 2013

21

Mild Aerobic Oxidative Palladium (II) Catalyzed C−H Bond Functionalization: Regioselective and Switchable C−H Alkenylation and Annulation of Pyrroles

Beck, Elizabeth M., Grimster, Neil P., Hatley, Richard, Gaunt, Matthew J.

Journal:

Journal of the American Chemical Society

Year:

2006

Language:

english

File:

PDF, 192 KB

english, 2006

22

Fluorogenic small molecules requiring reaction with a specific protein to create a fluorescent conjugate for biological imaging-what we know and what we need to learn

Baranczak, Aleksandra, Connelly, Stephen, Liu, Yu, Choi, Sungwook, Grimster, Neil P., Powers, Evan T., Wilson, Ian A., Kelly, Jeffery W., Blacklow, Stephen

Journal:

Year:

2014

Language:

english

File:

PDF, 1.70 MB

english, 2014

23

Rate-adaptive AV delay and exercise performance following cardiac resynchronization therapy

Shanmugam, Nesan, Prada-Delgado, Oscar, Campos, Ana Garcia, Grimster, Alex, Valencia, Oswaldo, Baltabaeva, Aigul, Jones, Sue, Anderson, Lisa

Journal:

Year:

2012

Language:

english

File:

PDF, 740 KB

english, 2012

24

Catalytic Asymmetric Transannulation of N H -1,2,3-Triazoles with Olefins

Kwok, Sen Wai, Zhang, Li, Grimster, Neil P., Fokin, Valery V.

Journal:

Angewandte Chemie International Edition

Year:

2014

Language:

english

File:

PDF, 461 KB

english, 2014

25

Catalytic Asymmetric Transannulation of N H -1,2,3-Triazoles with Olefins

Kwok, Sen Wai, Zhang, Li, Grimster, Neil P., Fokin, Valery V.

Journal:

Angewandte Chemie

Year:

2014

Language:

english

File:

PDF, 454 KB

english, 2014

26

Rhodium-Catalyzed Asymmetric Cyclopropanation via Azavinyl Carbenoids

Grimster, N., Zhang, L., Fokin, V.

Journal:

Year:

2010

Language:

english

File:

PDF, 72 KB

english, 2010

27

Direct Cu(II)-Catalyzed Arylation of Indoles: Switchable Regioselectivity

Phipps, R., Grimster, N., Gaunt, M.

Journal:

Year:

2008

Language:

english

File:

PDF, 72 KB

english, 2008

28

Type I Brugada electrocardiogram pattern during the recovery phase of exercise testing

Grimster, A., Segal, O. R., Behr, E. R.

Journal:

Year:

2008

Language:

english

File:

PDF, 170 KB

english, 2008

29

ChemInform Abstract: Catalytic Asymmetric Transannulation of NH-1,2,3-Triazoles with Olefins.

Kwok, Sen Wai, Zhang, Li, Grimster, Neil P., Fokin, Valery V.

Journal:

Year:

2014

File:

PDF, 23 KB

2014

30

An ortho -Iminoquinone Compound Reacts with Lysine Inhibiting Aggregation while Remodeling Mature Amyloid Fibrils

Fernandes, Luiza, Moraes, Nathalia, Sagrillo, Fernanda S., Magalhães, Augusto V., de Moraes, Marcela C., Romão, Luciana, Kelly, Jeffery W., Foguel, Debora, Grimster, Neil P., Palhano, Fernando L.

Journal:

ACS Chemical Neuroscience

Year:

2017

Language:

english

File:

PDF, 2.82 MB

english, 2017

31

A Study of the Reactivity of S(VI)-F Containing Warheads with Nucleophilic Amino-Acid Side Chains Under Physiological Conditions

Mukherjee, Herschel, Debreczeni, Judit, Breed, Jason, Tentarelli, Sharon, Aquila, Brian, Dowling, James, Whitty, Adrian, Grimster, Neil Patrick

Journal:

Organic & Biomolecular Chemistry

Year:

2017

Language:

english

File:

PDF, 3.52 MB

english, 2017

32

Proof of concept study of a novel pacemapping algorithm as a basis to guide ablation of ventricular arrhythmias

Li, Anthony, Davis, Joseph Samuel, Grimster, Alexander, Wierwille, Jeremiah, Herold, Keith, Morgan, Dennis, Behr, Elijah R, Shorofsky, Stephen, Saba, Magdi

Journal:

Year:

2018

Language:

english

File:

PDF, 907 KB

english, 2018

33

Discovery and Optimization of a Novel Series of Highly Selective JAK1 Kinase Inhibitors

Grimster, Neil P., Anderson, Erica, Alimzhanov, Marat, Bebernitz, Geraldine, Bell, Kirsten, Chuaqui, Claudio, Deegan, Tracy, Ferguson, Andrew D., Gero, Thomas, Harsch, Andreas, Huszar, Dennis, Kawatka

Journal:

Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 1.87 MB

english, 2018

34

Beyond cysteine: recent developments in the area of targeted covalent inhibition

Mukherjee, Herschel, Grimster, Neil P

Journal:

Current Opinion in Chemical Biology

Year:

2018

Language:

english

File:

PDF, 795 KB

english, 2018

35

Concealed conduction in atrial tachyarrhythmia illustrated in a heartbeat

Gonna, Hanney, Grimster, Alex, Roberts, David, Gallagher, Mark M.

Journal:

HeartRhythm Case Reports

Year:

2018

Language:

english

File:

PDF, 972 KB

english, 2018

36

High resolution map of aortic root tachycardia

Evranos, Banu, Leung, Lisa W M, Gonna, Hanney, Harding, Idris, Grimster, Alexander, Gallagher, Mark M

Journal:

Year:

2019

Language:

english

File:

PDF, 197 KB

english, 2019

37

High resolution map of aortic root tachycardia

Evranos, Banu, Leung, Lisa W M, Gonna, Hanney, Harding, Idris, Grimster, Alexander, Gallagher, Mark M

Journal:

Year:

2019

File:

PDF, 197 KB

2019

38

Discovery and optimization of covalent Bcl-xL antagonists

Mukherjee, Herschel, Su, Nancy, Belmonte, Matthew A., Hargreaves, David, Patel, Joe, Tentarelli, Sharon, Aquila, Brian, Grimster, Neil P.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2019

File:

PDF, 1.32 MB

2019

39

Discovery of (2 R )- N -[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]-1 H -indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a Potent and Selective Janus Kinase 1 Inhibitor

Su, Qibin, Banks, Erica, Bebernitz, Geraldine, Bell, Kirsten, Borenstein, Cassandra F., Chen, Huawei, Chuaqui, Claudio E., Deng, Nanhua, Ferguson, Andrew D., Kawatkar, Sameer, Grimster, Neil P., Rusto

Journal:

Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 756 KB

2020

40

Optimization of a Series of Potent, Selective and Orally Bioavailable SYK Inhibitors

Grimster, Neil P., Gingipalli, Lakshmaiah, Barlaam, Bernard, Su, Qibin, Zheng, XiaoLan, Watson, David, Wang, Haixia, Simpson, Iain, Pike, Andy, Balazs, Amber, Boiko, Scott, Ikeda, Timothy P., Impastat

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2020

File:

PDF, 1.31 MB

2020

41

The application of high content omics for comparability testing of an allogeneic cell therapy

Kearney, J., Li, L., Thwaites, T., Kheir, T. Bou, Marshall, D., Moss, D., Williams, A., Woodward, R., Grimster, S., Davies, S., Patel, S., Nuamah, R., Kadolsky, U., Kannambath, S., Bolt, H., Kleeman,

Journal:

Year:

2020

File:

PDF, 66 KB

2020

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